Investigating the role of Multidrug Resistance associated proteins in Caenorhabditis elegans nervous system

Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/493

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DC Field	Value	Language
dc.contributor.author	L.V, Shiji	-
dc.contributor.other	Babu, Kavita	-
dc.date.accessioned	2015-07-10T11:24:10Z	-
dc.date.available	2015-07-10T11:24:10Z	-
dc.date.issued	2015-07-10	-
dc.identifier.uri	http://hdl.handle.net/123456789/493	-
dc.description	MS10045	en_US
dc.description.abstract	Multidrug resistance associated proteins (mrps) belong to the C subfamily of ABC transporters. There are 9 mrps in C.elegans. Most of them are anion transporters. In this project we studied the role of MRPs in neuronal signaling; more precisely in dopaminergic signaling. We utilized SWIP (Swimming induced paralysis) assay to characterize mrps for their role in dopaminergic signaling. Next rescue was performed with exogenous dopamine (DA).In this study we identified mrp-3 as a probable mrp candidate that could play a role in dopaminergic signaling. Further studies will be done by utilizing various dopaminergic pathway mutants to identify the role of mrp-3 in the pathway.	en_US
dc.description.sponsorship	IISER M	en_US
dc.language.iso	en	en_US
dc.publisher	IISER M	en_US
dc.subject	Proteins	en_US
dc.subject	Biology	en_US
dc.subject	Nervous System	en_US
dc.title	Investigating the role of Multidrug Resistance associated proteins in Caenorhabditis elegans nervous system	en_US
dc.type	Thesis	en_US
Appears in Collections:	MS-10

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