Studies on the β-C(sp3) -H Functionalization Toward the Synthesis of β-Arylated Unnatural Amino Acid Derivatives

Abstract

The thesis entitled “Studies on the β-C(sp 3 )-H functionalization toward the synthesis of β-arylated unnatural amino acid derivatives” covers five chapters including Chapter 1 describes with a preamble to C-H functionalization, Chapter 2 reveals the bidentate directing group aided Pd-catalyzed β-C(sp 3 )-H arylation of unnatural amino acids towards the construction of pyrrolidinone derivatives, Chapter 3 reveals assembling of 4-aryl 2-piperidones, piperidines, antituberculosis molecule (Telacebec) and its analogues via Pd(II)-catalyzed β- C(sp 3 )-H arylation, Chapter 4 reveals the application of Pd(II)-catalyzed, directing group-assisted C-H arylation strategy for the synthesis of azobenzene- based unnatural amino acid scaffolds and peptides, Chapter 5 reveals the pyridine N-oxide directing group-directed remote functionalization of phenylacetamides, phenylglycine and heterocyclic amides via Pd-catalyzed regioselective γ- C(sp 2 /sp 3 )-H and δ-C-(sp 2 )-H functionalization of carboxamides.