Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/2171
Title: | Study of Lipid Membranes Interaction With Cholesterol and Functional Peptides |
Authors: | Kumar, Harshit |
Keywords: | Lipid Membranes Cholesterol Functional Peptides |
Issue Date: | Apr-2023 |
Publisher: | IISER Mohali |
Abstract: | Cellular membranes are important targets for many membrane-active peptides and drug compounds. Here we are interested in deciphering how lipid membranes are perturbed by several membrane-active molecules, such as cholesterol and crucial peptides such as α- amylase. We employ phase-separated ternary lipid model membranes in the form of giant unilamellar vesicles (GUVs) to simulate raft-like structures that have been proposed to gov- ern many important processes in plasma membranes (e.g., intracellular singling and traf- ficking). Specifically, we use phase contrast microscopy to interrogate how those membrane additives modulate the phase behaviour of free-standing GUVs and the bending rigidity of the membranes. We quantify these changes in the bending rigidity of the lipid membrane and predict cellular characteristics. |
Description: | Embargo period |
URI: | http://hdl.handle.net/123456789/2171 |
Appears in Collections: | MS-18 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Need To Add…Full Text_PDF | 15.36 kB | Unknown | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.