Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/2171
Title: Study of Lipid Membranes Interaction With Cholesterol and Functional Peptides
Authors: Kumar, Harshit
Keywords: Lipid Membranes
Cholesterol
Functional Peptides
Issue Date: Apr-2023
Publisher: IISER Mohali
Abstract: Cellular membranes are important targets for many membrane-active peptides and drug compounds. Here we are interested in deciphering how lipid membranes are perturbed by several membrane-active molecules, such as cholesterol and crucial peptides such as α- amylase. We employ phase-separated ternary lipid model membranes in the form of giant unilamellar vesicles (GUVs) to simulate raft-like structures that have been proposed to gov- ern many important processes in plasma membranes (e.g., intracellular singling and traf- ficking). Specifically, we use phase contrast microscopy to interrogate how those membrane additives modulate the phase behaviour of free-standing GUVs and the bending rigidity of the membranes. We quantify these changes in the bending rigidity of the lipid membrane and predict cellular characteristics.
Description: Embargo period
URI: http://hdl.handle.net/123456789/2171
Appears in Collections:MS-18

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