Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1915
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dc.contributor.authorVenkatesh, Achuthan Raja-
dc.date.accessioned2022-12-17T06:50:02Z-
dc.date.available2022-12-17T06:50:02Z-
dc.date.issued2022-04-
dc.identifier.urihttp://hdl.handle.net/123456789/1915-
dc.description.abstractThe cytoplasm is as a complex, heterogeneous environment with substructures spanning the nanoscale to the microscale. The heterogeneity produces a plethora of physicochemical properties that cells exploit to exact various biochemistries with spatiotemporal precision. In this context, the role of position-dependent viscosity remains poorly understood. Here, we propose an interaction- free mode of cellular compartmentalisation that relies on inhomogeneous diffusion (arising from space-dependent viscosity) and study its effects on mesoscale organisation via agent-based mod- elling. Such viscophoretic accumulation also affects the rate of interaction-driven clustering. In silico FRAP simulations reveal emergent turnover timescales arising from heterogeneous dynamics. Microrheology-based calculations identify anomalous diffusive behaviours manifesting as a result of such inhomogeneous diffusion. We also probe inhomogeneous diffusion in the case of subcellu- lar viscous granules arising during viscoadaptation in cells, and identify how timescales depend on granule-packing parameters.en_US
dc.language.isoen_USen_US
dc.publisherIISER Mohalien_US
dc.subjectcompartmentalisationen_US
dc.subjectsubcellularen_US
dc.subjectInhomogeneousen_US
dc.titleEffect of Inhomogeneous diffusion on subcellular compartmentalisationen_US
dc.typeThesisen_US
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