Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1818
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKrishnan, Nimisha-
dc.contributor.authorChaudhuri, A.-
dc.contributor.authorToda, Takashi-
dc.date.accessioned2021-12-14T10:33:25Z-
dc.date.available2021-12-14T10:33:25Z-
dc.date.issued2020-04-
dc.identifier.urihttp://hdl.handle.net/123456789/1818-
dc.description.abstractMotor proteins play a very pivotal role in many cellular processes including cell cycle. Kinesin motor proteins move on microtubule tracks and are known to be extremely important during the process of mitosis. A defect in these proteins can adversely affect the cell cycle even causing cell death. In this thesis, we experimentally explored various situations. In fission yeast over expression of kinesin-5/cut7 and the presence of cut7-rigor are extremely toxic for cell growth and showed mono polar cell. But cut7-rigor when expressed with cut7-22 rescues temperature sensitivity of cut7-22. A few Kinsen-14 kifc1, kifc3, kif25 and Eg5 from the human and macaque when expressed in fission yeast cell resulted in varying level of toxicity for cell growth. We also theoretically explored dynamical instability of microtubules which is known to increase during mitosis. The model shows length versus time traces of microtubule instability which are similar to experimental results.en_US
dc.language.isoenen_US
dc.publisherIISERMen_US
dc.subjectmicrotubuleen_US
dc.subjectmicrotubule kinesinsen_US
dc.subjectcell cycleen_US
dc.subjectmitosisen_US
dc.titleA study on mitosis : role of kinesins and microtubule instabilityen_US
dc.typeThesisen_US
Appears in Collections:MS-15

Files in This Item:
File Description SizeFormat 
MS15206.docx12.88 kBMicrosoft Word XMLView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.