Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1732
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dc.contributor.authorNivedha, B.-
dc.contributor.authorMishra, Shravan Kumar-
dc.date.accessioned2021-12-13T05:54:39Z-
dc.date.available2021-12-13T05:54:39Z-
dc.date.issued2021-06-28-
dc.identifier.urihttp://hdl.handle.net/123456789/1732-
dc.description.abstractPre-mRNA splicing by the spliceosome is one of the steps where regulation of gene expression occurs. Various ubiquitin-like proteins (UBLs) have been shown to regulate pre-mRNA splicing. The UBL Hub1 is known to play a role in alternative splicing in Saccharomyces cerevisiae through its well-known surfaces. This study shows that the recently identified novel surface of Hub1 in Schizosaccharomyces pombe plays a significant role in cell growth and splicing. The various approaches of bioinformatic analysis, genetics and splicing assays suggest a possible link between Hub1 and transcription. This study also shows that Hub1 selectively modifies the spliceosome and that it might play a role in the transition of the spliceosome. Therefore, this study addresses the mechanism and function of Hub1 in Schizosaccharomyces pombe.en_US
dc.language.isoenen_US
dc.publisherIISERMen_US
dc.subjectUBL Hub1en_US
dc.subjectmRNAen_US
dc.subjectPre-mRNAen_US
dc.titleRole of the unconventional UBL Hub1 in pre-mRNA splicingen_US
dc.typeThesisen_US
Appears in Collections:MS Dissertation by MP-2018

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