Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1508
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAgarwala, Prasad, N.G. Amisha-
dc.date.accessioned2021-12-08T10:02:55Z-
dc.date.available2021-12-08T10:02:55Z-
dc.date.issued2020-05-
dc.identifier.urihttp://hdl.handle.net/123456789/1508-
dc.description.abstractWe investigated X-linked variation for immune response, and its role in sexually dimorphic immune defenses. Immunity has been shown to be subject to Intralocus Sexual Conflict (IaSC), and it is reported that sexually antagonistic variation is likely to be concentrated on the X chromosome. We used laboratory-based populations of Drosophila melanogaster selected for increased survivorship against Pseudomonas entomophila, a gram-negative bacterial pathogen. After 160 generations of selection, X chromosomes were cloned from I (selected) and S (control) populations, and expressed in flies where the other chromosomes came from the ancestral baseline population to create 30 X chromosome lines respectively. To determine the result of selection on the X chromosome in these populations, we subjected male and female flies from these lines to a P. entomophila infection and assayed their survivorship for 96 hours post-infection. We were unable to detect any effect of the X chromosome on the immune response in these populations as there was no difference in survivorship post-infection of flies carrying the X chromosome from the selected or control population.en_US
dc.language.isoenen_US
dc.publisherIISERMen_US
dc.subjectDrosophilaen_US
dc.subjectimmunityen_US
dc.subjectmelanogasteren_US
dc.subjectchromosomeen_US
dc.titleX doesn’t mark the spot: Role of the X chromosome in improved immunity in Drosophila melanogasteren_US
dc.typeThesisen_US
Appears in Collections:MS-15

Files in This Item:
File Description SizeFormat 
MS15052.docx12.57 kBMicrosoft Word XMLView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.