Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1419
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dc.contributor.authorDubey, Pankaj-
dc.contributor.authorViswanathan, K.S.-
dc.date.accessioned2021-07-23T10:05:26Z-
dc.date.available2021-07-23T10:05:26Z-
dc.date.issued2019-05-
dc.identifier.urihttp://hdl.handle.net/123456789/1419-
dc.description.abstractConformational preferences of α-amino acids were studied using matrix isolation infrared and ab initio computations. As a result of this study, the factors that determine the conformational stability of amino acids were recognized. It turns out that the low energy conformers of α-amino acids prefer predominantly two types of backbone structures (i.e. the relative orientation of COOH and NH 2 moiety) and these two preferred orientations were labelled as “type I or II”. An analysis of the conformer population indicates that ~80 % of the amino acid populations take up backbone type I and II structures. For these backbone structures, the various orientations of the side chain in the amino acids gave rise to a variety of conformers for each amino acid. The question was then addressed to see if these preferred backbone structures had a role to play in the intrinsic propensity and the structural preferences in peptides.en_US
dc.language.isoenen_US
dc.publisherIISERMen_US
dc.subjectConformational Landscapeen_US
dc.subjectAmino Acidsen_US
dc.subjectAb initio Computationsen_US
dc.titleRestricted backbone preference in the conformational landscape of amino acids: Do they have a role to play in the peptide structure?en_US
dc.typeThesisen_US
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