Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1286
Title: Understanding the impact of High- Sugar Diet on the gut homeostasis of Drosophila melanogaster
Authors: V. V, ASHITHA
Mandal, Sudip
Keywords: homeostasis
High Sugar
Drosophila
hyperglycemia
Issue Date: 25-Nov-2019
Publisher: IISERM
Abstract: Diet of an organism has a great influence on its health and homeostasis. Considering that diabetes and related metabolic disorders are growing health problems worldwide, we are trying to understand the effects of High Sugar Diet on intestine using the model organism Drosophila melanogaster. In this study, we fed flies on high sugar diet (1M-sugar) sugar to provide a condition that resembles hyperglycemia. Our results demonstrate the effect of high sugar diet in the gut morphology, cell size, cell death, and some signalling pathways that are critical for maintaining gut homeostasis -We conducted parallel experiments to study the impact of HSD on gut commensal bacteria and observed a significant decrease in the number of gut commensal bacteria in the gut of high sugar diet fed flies. This had a natural consequence on the expression of genes involved in immune pathways.
URI: http://hdl.handle.net/123456789/1286
Appears in Collections:MS-14

Files in This Item:
File Description SizeFormat 
MS14183.pdf55.39 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.