Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1209
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dc.contributor.authorBirari, Varun Sanjay-
dc.contributor.authorSinha, Somdatta-
dc.date.accessioned2019-11-22T07:39:50Z-
dc.date.available2019-11-22T07:39:50Z-
dc.date.issued2019-11-21-
dc.identifier.urihttp://hdl.handle.net/123456789/1209-
dc.description.abstractThe complete set of neurons and their synaptic connectivity in the worm Caenorhab- ditis elegans has been worked out experimentally. These neurons, with their chem- ical and electrical synapses, form a network through which informational cues are transferred for the worm to generate appropriate behavioral responses. Thus, the C. elegans neuronal connectivity presents itself as an ideal system to understand if/how connectivity pattern can explain different behaviors observed in a worm. I have used the network theory to analyze the neuronal connectivity pattern in C. elegans, and looked for functional correlations. Here, first I have experimentally analyzed the role of EXP-1 protein in AWC neuron mediated chemotaxis behavior, using chemotaxis assay. Then, I have analyzed both undirected and directed neuronal networks based on types of synaptic connections, and compared their properties to the ones reported in literature. Using modularity and shortest path analysis, I have shown how con- nectivity pattern underlies the chemotaxis behavior in worms, and propose alternate neuronal circuits for navigation in C. elegans.en_US
dc.language.isoen_USen_US
dc.publisherIISERMen_US
dc.subjectBiologyen_US
dc.subjectCaenorhabditis elegansen_US
dc.subjectCommunity Analysisen_US
dc.subjectEgg Synchronizationen_US
dc.subjectChemotaxis Assayen_US
dc.titleAnalysis of neuronal networks in Caenorhabditis elegansen_US
dc.typeThesisen_US
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