http://hdl.handle.net/123456789/270 Dissertation submitted by MS - 08 batch as part of their course Tue, 16 May 2023 17:10:47 GMT 2023-05-16T17:10:47Z http://hdl.handle.net/123456789/1739 Title: Magnetically separable nano Fe3O4 as highly efficient and reusable heterogeneous catalyst for the regio-and stereoselective synthesis of β-amino alcohols Authors: Kumar, Amit; Babu, S.A. Abstract: Magnetically recoverable and nano Fe3O4-catalyzed ring opening of aliphatic, alicyclic and aromatic epoxides with a variety of amines under solvent free condition is reported . Nano Fe3Os- catalyzed epoxide opening gave various β-amino alcohols in good to excellent yields with very high regio-and stereoselectivity. The catalyst can be recovered and reused up to ten cycles. Fri, 26 Apr 2013 00:00:00 GMT http://hdl.handle.net/123456789/1739 2013-04-26T00:00:00Z http://hdl.handle.net/123456789/1738 Title: A study on perception of “quality” of competitors by male Drosophila melanogaster under different levels and quality of sperm competition. Authors: Khaleel, Mehreen; Prasad, N.G. Abstract: In promiscuous species, females are known to store sperms from different mating males. Multiple mating leads to sperm competition in males. Males adapt various strategies to compete for both reproductive and fertilization success. Drosophila, males are known to show plasticity in reproductive behaviour under different level of sperm competition. Studies suggest male reproductive response to number of competitor, but there is no such study which addresses sperm competition as the quality of the sperm. In the present study, I ask if males can perceive the quality and of competition and what reproductive response do male adapt to compete to this competition. I found a highly significant effect of treatment on the copulation duration of the target males under precopulatory competition. There was no effect on progeny sired by the target male, which were conditioned in early life. Tue, 04 Jun 2013 00:00:00 GMT http://hdl.handle.net/123456789/1738 2013-06-04T00:00:00Z http://hdl.handle.net/123456789/1737 Title: Computational Aspects of Representation Theory Authors: Kumar, Nikhil; Kulshrestha, Amit Abstract: Abstract Not Available Wed, 05 Jun 2013 00:00:00 GMT http://hdl.handle.net/123456789/1737 2013-06-05T00:00:00Z http://hdl.handle.net/123456789/1736 Title: AMYLOIDOGENIC INTRINSICALLY DISORDERED PROTEINS: CONFORMATIONAL PLASTICITY, MEMBRANE BINDING AND AGGREGATION Authors: Bhasne, Karishma; Mukhopadhyay, Samrat Abstract: Natively unfolded or intrinsically disordered proteins (IDPs) possess astonishing conformational plasticity that allows them to adopt a wide range of structures. My work involves the study of two amyloidogenic IDPs, namely -synuclein and tau, aggregation of which are involved in Parkinson’s and Alzheimer’s diseases, respectively. -synuclein adopts a helical structure upon binding to the membranes. However, the high-resolution structural and dynamical insights of the membrane bound -synuclein remain elusive. We took the advantage of the fact that -synuclein does not have any tryptophan and incorporated single Trp mutant along the polypeptide chain. These Trp mutants of the - synuclein have been used as a crucial scout. The fluorescence anisotropy map illuminates the structural rigidification of various regions of the polypeptide chain mediated by membrane binding-induced folding. In order to obtain the depth-profile of different segments of α-synuclein from the membrane surface, we utilized a unique and reliable indicator, such as red-edge excitation shift (REES), which is utilized to monitor the dynamics of restricted water molecules at the membrane-water interface.1,2 The membrane-water interface comprises of ~ 15 Å thick water layers having strongly bound (restrained) water (also known as biological water) and has been hypothesized to play a pivotal role in a variety of crucial biomolecular processes. In order to achieve the distance profile between the membrane surface and the protein residues, we have used fluorescence resonance energy transfer (FRET) experiments between fluorescently labeled membrane and Trp locations of -synuclein. Taking together all the results from these fluorescence readouts, we have proposed a model that elucidates the precise conformation of the -synuclein protein on the negatively charged membrane. Additionally, we have also investigated the influence of -synuclein in the amyloid aggregation of tau protein that is implicated in human neurodegenerative disorders. Mon, 01 Apr 2013 00:00:00 GMT http://hdl.handle.net/123456789/1736 2013-04-01T00:00:00Z