http://hdl.handle.net/123456789/1320 Dissertation submitted by MP -2012 batch as part of their course. 2023-05-15T21:05:58Z http://hdl.handle.net/123456789/1023 Title: Novel role of the homeotic gene deformed (dfd) in progenitor fate determination during haematopoiesis in Drosophila melanogaster Authors: Nayak, Adyasha Abstract: Exploration of haematopoiesis in Drosophila has been a contributing factor towards providing insights into signalling pathways and cell biological processes. The development and functionality of the larval haematopoietic organ-the lymph gland-has dominated much of the studies. Studies during early developmental stages have provided a layout of the events governing lineage choice determination of blood precursors. However, not much has been described beyond the spatial information and sequence of transcription factors involved. These early blood precursors develop from a specified cluster of cells-the blood anlage-under the regulation of some key factors. The procephalic primordium, from which the blood anlage forms, is regulated by the balanced interaction between homeotic and patterning genes. The focus of this project has been to understand the direct regulation of homeotic and patterning genes on the blood anlage, and ultimately on the fate choice determination of precursor cells. Here, we report the novel role of the homeotic gene deformed in blood precursor specification. The dfd expressing cells contribute to the population of mature blood cells; dfd is also a direct influencer of the fate specification of these cells, consequentially affecting the mature blood population in the embryo. The specific regulation by homeotic genes can provide a better understanding of the lineage diversification of progenitor cells. Further analysis could also provide a glimpse into signalling cascades involved in the development of certain cancers 2018-11-28T00:00:00Z http://hdl.handle.net/123456789/623 Title: Review of Discrete Newtonian Cosmology Authors: Mulani, Imrankhan B. Abstract: Large scale properties of the universe can be explained by Einstein's general theory of relativity. A-CDM model incorporating general relativity predicts the accelerated expansion of universe and large scale distribution of galaxies. Structure formation equation obtained from this model are non linear and difficult to solve. Newtonian theory of gravity can be applied to situations after decoupling of matter and radiation. Newton himself tried to apply his theory to universe but failed. Reason for failure is that he considered static model with infinite stars. This result in divergences. The divergences can be avoided by assuming finite number of particles interacting only through gravitational attraction. This thesis is review of Newtonian cosmological theory of finite number of discrete particles interacting through gravitational attraction, also with Newtonian version of cosmological constant. Exact solution we get for Newtonian equations are homothetically expanding background with comoving positions constituting a central configuration. The scale factor satisfy Rauchaudhuri and Friedmann equations without making any uid approximation. These solutions can be linearised to get perturbation theory for structure formation calculations. 2016-09-05T00:00:00Z http://hdl.handle.net/123456789/621 Title: Quark Mass Matrices & Textures Authors: Thakur, Ashish Abstract: Texture speci c mass matrices provide a good example of \Bottom-Up"approach to deal with the fermion mass matrices and their implications for avour physics. In the context of quarks, we have studied the implication of \Weak Basis"transformations and the naturalness condition. Interestingly, we find that the present data related to quark mixings and masses allow us to deduce almost a unique set of viable quark mass matrices 2016-09-05T00:00:00Z http://hdl.handle.net/123456789/617 Title: Dynamics of Interacting Colloids Authors: Subramanian, Srikanth Abstract: Abstact Presented here are the results of analytical and numerical simulations for colloidal systems driven by ratcheting potential switching on and o stochastically. We observe the variation of the resultant directed current as a function of the ratcheting frequency. In the case of an interacting colloidal system, molecular dynamics [3] has revealed resonance of directed current with ratcheting frequency. The analytical tools necessary, the theoretical paradigm of non-equilibrium statistical mechanics and stochastic processes(relevant parts) are also discussed in detail. 2015-08-13T00:00:00Z